Sant'Antioco Island Vacations from $387

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Your Sant'Antioco Island Vacation

Make planning your next epic adventure effortless with a Sant'Antioco Island vacation package. If it's coastal beaches, views and history you're after, you won't be disappointed. During your trip to Sant'Antioco Island, you'll want to get around to a few of its top cities. What shouldn't you miss? Calasetta. Expedia has hotels, flights, car rentals and more to help you create your very own tailored Sant'Antioco Island vacation today.

The Latest Sant'Antioco Island vacation packages

Price found within the past 48 hours. Click for updated prices.
Eco Hotel Orlando
 VOI Tanka Selected
Chia Laguna - Hotel Village
VOI Tanka Village
Arbatax Park Resort - Ville del Parco
Don't see what you're looking for?
See all available trips from Columbus to Sant'Antioco Island
View all trips

Discover the most popular places to visit in Sant'Antioco Island

What to do in Sant'Antioco Island

Sant'Antioco Island Hotel Deals

Hotel Le Sabbie Calasetta

Hotel Le Sabbie Calasetta

3 out of 5
Vico Le Sabbie, 4, Calasetta, SU
$89 nightly
The price is $102 total per night from Sep 22 to Sep 23
$102 total
Sep 22 - Sep 23
Total with taxes and fees
9/10 Wonderful! (75 reviews)
"Friendly staff, comfy bed and quiet neighbourhood"

Reviewed on Aug 14, 2025

Hotel Le Sabbie Calasetta
MuMA Hostel

MuMA Hostel

Lungomare Colombo 25, Sant'Antioco, SU
Fully refundableReserve now, pay when you stay
9/10 Wonderful! (129 reviews)
"Everything was perfect!"

Reviewed on Sep 1, 2024

MuMA Hostel
Lu’ Hotel Maladroxia

Lu’ Hotel Maladroxia

4 out of 5
Via Golfo di Palmas, Maladroxia, Sant'Antioco, SU
$134 nightly
The price is $157 total per night from Sep 21 to Sep 22
$157 total
Sep 21 - Sep 22
Total with taxes and fees
8.4/10 Very Good! (95 reviews)
Great beachfront hotel
"Lovely structure, modern and super clean with great staff that made the stay even better. The reception manager, especially, kindly furnished suggestions on what to visit in the areas and, in particular, his home town of Iglesias. Much appreciated! Would definitely return! Great stay and base for ..."

Reviewed on Jul 8, 2025

Lu’ Hotel Maladroxia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.